Diagnostic tests
Carci Reagent is a diagnostic test kit for self-testing to detect approximate amounts of monohydroxyphenol metabolites (tyrosine) in urine. It is a chemical chromogenic method. The aim is to reveal the presence of the sought substance in the tested sample through chemical reactions that cause visible color changes. The result can then be compared with a color scale. The tyrosine receptor-protein kinase erbB-2 (ERBB2) is involved in transcription regulation and can be used as a receptor for various types of cancer.
ERBB2 has been scientifically described as a marker for:
- Gastroesophageal cancer
- Breast cancer
- Lung cancer
- Gallbladder and pancreatic cancer
- Uterine carcinoma
The basic principle of the test is based on the improved method of Millon's reagent, where the increased amount of monohydroxyphenol metabolites (tyrosine) (monohydric phenolic amino acids and their metabolites) in urine is monitored. Based on the color change of the mixture in the ampoule after adding 3 ml of morning urine (midstream urine), the reaction's color cascade can be used to determine whether the urine samples contain increased amounts of the mentioned metabolites. The reagents in the ampoule and the content of tyrosine in the urine exhibit a characteristic chromogenic reaction, which can be used for the clinical diagnosis of intracellular metabolic abnormalities (detection of possible changes or disorders in metabolic exchange within human cells). The determined approximate tyrosine content in the urine (according to the attached table from 0 - 2000 mg per liter of urine) reacts with a chemical reagent, and depending on its amount, it will change color. According to the attached color scale, the test result can be read from no. 1 to no. 8.
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